Roma vs Lazio predictions, Betting tips and Odds |29/09/2018| Updated for January 2026

Updated: 11th January 2026
Roma will welcome their rivals Lazio to the Stadio Olimpico this Saturday. The afternoon kick-off will see Roma wanting to bounce back from last week’s loss to Bologna, meanwhile their Italian counterparts are still on a high from their 4-1 trouncing of Genoa.
The home side Roma are tipped as the favourites, with their odds trading at 7/5 as part of William Hill’s Roma vs Lazio predictions. Meanwhile, Simone Inzaghi’s men are betting as 9/5 outsides, with a draw projecting at a 13/5 pick.
Roma will have to be wary of their opponents who have impressed in recent performances under Inzaghi. A 4-1 victory over Genoa that saw goals from Ciro Immobile and Serge Milinkovic-Savic prove that they possess valuable attacking outlets that could unlock the Roma defence and we’re wagering that either Savic or Immobile will make it onto the score-sheet again.
The I Giallorossi will be looking to Edin Dzeko to bring them some good fortune in front of goal, and if they are to snatch a win away from Lazio on home turf they will need to be clinical with their chances.
But if Roma’s recent performances are anything to go by, then projecting a defeat for Eusebio De Francesco’s men might be the wisest tip to bet on. We’ve made them one of our picks to lose by two goals to one against Lazio, trading at 9/1, but read ahead and you might find a better bet to punt on.

Dzeko uses his strength to score against Chievo, and is tipped to cause more defensive problems against Lazio
Roma vs Lazio predictions: Head to head
(Most recent first): Roma 0-0 Lazio, Roma 2-1 Lazio, Roma 1-3 Lazio
In recent results the spoils of war have been shared between Roma and the Biancocelesti, and it’s difficult to tip either side towards a victory for this Saturday’s clash .
Roma's subsequent meetings with Lazio in 2019 showed a competitive edge, with Roma securing a 3-2 victory in March. This win demonstrated their ability to recover despite earlier challenges in the season.
Meanwhile, Lazio managed a solid performance with a 1-1 draw in September, showcasing their resilience and tactical adaptability. Notably, both teams seemed evenly matched, heightening the anticipation for their next showdown.
As part of our Roma vs Lazio predictions, we’ve provided some match bets which might just help you decide on which team to wager on.
Roma vs Lazio match bets: Prediction, best bet, handicap tips
If Roma have learnt anything from their previous performances, they will want to retain a solid-looking defence against Lazio’s star-studded attack, who have won five of their last eight away games.
Kostas Manolas and Fredrico Fazio will need to have their wits about them, otherwise they’ll be on the wrong end of another attacking master-class. Players like Immobile and Savic are efficient in their scoring and will pounce on any opportunities that are presented them.
During the 2018-2019 season, Ciro Immobile continued his impressive form by scoring 15 goals in Serie A, maintaining his status as a key player for Lazio.
Edin Dzeko was a major influence for Roma, contributing significantly to their attacking prowess, despite some inconsistencies.
On the other hand, Roma’s attack can also be threatening. Given that their bench boasts of players like Stephan El-Shaarawy, it wouldn’t be all too surprising if they held Lazio to a draw.
This might be the safest bet to place, and with odds of 9/1, making your pick a draw in line with our Roma vs Lazio predictions to reap some good money.

Serge Milinkovic-Savic provides a genuine goal-scoring threat on the counter that Roma’s fullbacks will have to be wary of.
Coach Eusebio Di Francesco integrated more flexible formations to strengthen Roma's midfield control, which paid off in key matches.
Simone Inzaghi encouraged an aggressive wing play style for Lazio, capitalising on their swift wingers to create scoring opportunities. These tactical shifts notably impacted their standings, reflecting in tighter defensive strategies and varied attack patterns, adding unpredictability in upcoming derbies.
Our second bet slightly contradicts our first, but we think it’s good to cover all bases by providing an alternative set of odds in the penultimate installation of our Roma vs Lazio predictions.
It might be that Roma’s poor performances of late will have inspired the team to return to their winning ways and what better way to do it then against your local rivals on home turf?
We’ve tipped them to not only win, but to do it by scoring under 2.5 goals.
Besides, a hard-fought victory against Inzaghi’s men who are on a winning high seems like the perfect tonic for their blues, and we’ve made them our pick to come up with the goods on Saturday.
Roma To Win 1-0 10/1
Roma come into the game with seven goals conceded in three games, and this is their worst start to a Serie A campaign since 2010/11, when they also had five points from the opening five matchdays.
A leaky defence could be the least of their problems, considering that their attacking trio has either failed to convert crucial chances in front of goal, or have seen red against their opponents.
Our betting tipsters have put De Francesco’s men at a disadvantage; they are down a goal before the start of play, with odds trading at 10/3 as part of our Roma vs Lazio predictions.
The betting markets adapted to these developments, with fluctuating odds reflecting Roma's unpredictable defensive shifts and Lazio's consistent attacking display.
Bettors found value in unpredictable outcomes, as both teams demonstrated the capacity for surprise results during the season.
The post Roma vs Lazio predictions, Betting tips and Odds |29/09/2018| appeared first on William Hill News.
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